About Pexion « Pexion

The low affinity partial benzodiazepine receptor agonist imepitoin (Pexion™, Boehringer Ingelheim) is licensed for treating canine epilepsy, has a fast onset of action in dogs and has demonstrated anxiolytic properties in rodent models. This case series reports on the use of imepitoin in a group of dogs identified as having fear/anxiety based problems. Twenty dogs were enrolled into the study, attended a behaviour consultation and underwent routine laboratory evaluation.

The main measure of effectiveness was the number of seizures in a month. The study also looked at the proportion of dogs that had no seizures. During the follow up period, owners completed an eliciting context diary sheet every time their dog was exposed to an eliciting context identified in the baseline period, and these were submitted to the investigators every two weeks. These diaries were scored and a telephone call to the owner was arranged to review progress. Transient ataxia was reported very commonly during a clinical trial for noise phobia and occurred early in the treatment course. In more than half of the dogs that experienced ataxia during this clinical trial the signs resolved spontaneously within 24 hours in spite of continued treatment and in half of the remaining dogs within 48 hours. The claim for the treatment of noise phobia is based on a pivotal field study which investigated a 3 day course of treatment for a noise event associated with fireworks.

The combined treatment duration in both successive phases of the study was 24 weeks. Pexion 400mg is for the treatment of primary epilepsy in dogs. It is a white, oblong tablet supplied in 100mg and 400mg tablets, either individually or in packs of 100.

What Will My Dogs Life Be Like On Pexion?

For this reason, careful consideration should be given before deciding to switch a stabilized dog onto imepitoin from a different treatment. In non-responders, an increase in seizure frequency may be observed.

The effects of using medications such as SSRIs and TCAs can typically take around 3–5 weeks to become apparent . Benzodiazepines have a faster onset of action , but no benzodiazepines are licensed in any form for use in dogs in the EU nor available as veterinary formulations in the US. If you notice any side effects, even those not already listed in this package leaflet or you think that the medicine has not worked, please inform your veterinary surgeon.

In the high-dose group, the occurrence of the 4th generalized tonic-clonic seizure or a cluster seizure was the most frequent exit criterion, while suspected adverse reactions , consent withdrawal and non-compliance were rare reasons. In the low-dose group, a similar distribution was seen, with 4th generalized tonic-clonic seizure seen in 13 cases and cluster seizure in 11 cases being most frequent.

How Long Does Phenobarbital Stay In A Dog’s System?

Levetiracetam appears to be relatively safe for both dogs and cats, but studies are still ongoing to investigate any adverse effects it may have. It takes five to six half-lives for drugs to be fully eliminated from your system. Phenobarbital is metabolized by the liver and excreted in the urine. It can be detected in the urine for up to 15 days after a dose. If you take a urine drug screen while on phenobarbital, it will likely test positive for barbiturates.

While more male than female dogs were included, the treatment groups did not differ in their age and body weight . RxList does not provide medical advice, diagnosis or treatment. No definitive conclusions can be drawn on the effectiveness of imepitoin as an add-on therapy to phenobarbital, potassium bromide and/or levetiracetam from the limited studies available (see section “Interactions”). For orders that contain a signed courier medicine you will only be able to select our express courier option, and a signature will always be required on delivery. This is to ensure that the medication is fully tracked from the moment it leaves our Pharmacy until you receive it. All i can say is that our bitch has been on epiphen since she was 5, she is now 11 with no further episodes and no side effects. She is very active and does a full season picking up 3-4 days a week every year with no problems.

• Owners should consult their vet and explore all the possibilities when dealing with an epileptic dog.
• It is not known whether sulfacetamide sodium and sulfur topical will harm an unborn baby.
• Phenobarbital is metabolized by the liver and excreted in the urine.
• It is also likely that your vet may need to adjust your dog’s dose, and will therefore need to see your dog regularly.
• My 8 year old Labrador has suffered seizures since he was 2, no explanation has ever been found as to why but unusually he only ever has them in walks, never when he’s at rest which is the usual time for a dog to have a seizure.

The low-dose animals received a respective number of placebo tablets matching in size and appearance to the 100 and 400 mg imepitoin tablets, plus one capsule containing 1 mg/kg imepitoin as granulated tablet material. Both, tablets and capsules were dispensed at a local pharmacy, where capsules were custom filled according to the body weight of the individual dog.

Health & Behaviour

To prevent accidental ingestion, the bottle cap should be replaced immediately after withdrawing the required number of tablets for one dose. The item/s you selected is an authorised veterinary medicine. To complete your order one of our qualified staff must authorise the item is suitable for use. Please select the pet intended for use or create a new one. The owners also evaluated the overall effect of treatment based on previous New Year’s Eve fireworks experiences with the dogs. The owners of 66 percent of dogs receiving Pexion scored the overall treatment effect as excellent or good, compared with 25 percent of dogs receiving the placebo.